Version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2) is the recommended tool to assess the risk of bias in randomized trials included in Cochrane Reviews. RoB 2 is structured into a fixed set of domains of bias, focussing on different aspects of trial design, conduct, and reporting. Within each domain, a series of questions (‘signaling questions’) aim to elicit information about features of the trial that are relevant to risk of bias. A proposed judgment about the risk of bias arising from each domain is generated by an algorithm, based on answers to the signaling questions. Judgment can be ‘Low’ or ‘High’ risk of bias, or can express ‘Some concerns’. Research in the field has progression and RoB 2 reflects current understanding of how the causes of bias can influence study results, and the most appropriate ways to assess this risk. However, there is limited training on the use of RoB 2. Therefore, this symposium is intended to focus on RoB 2.